Open AccessInsulin Aspart in Diabetic Pregnancy: State of the Art
Author(s) -
Elisabeth R. Mathiesen
Publication year - 2008
Publication title -
women's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.363
H-Index - 39
eISSN - 1745-5065
pISSN - 1745-5057
DOI - 10.2217/17455057.4.2.119
Subject(s) - medicine , insulin aspart , postprandial , pregnancy , insulin , hypoglycemia , insulin analog , diabetes mellitus , population , neonatal hypoglycemia , endocrinology , type 1 diabetes , fetus , obstetrics , gestation , gestational diabetes , human insulin , environmental health , biology , genetics
Pregnancy in women with diabetes is associated with an increased risk of obstetric complications and perinatal mortality. Maintenance of near-normal glycemia during pregnancy can bring the prevalence of fetal, neonatal and maternal complications closer to that of the nondiabetic population. Changes in insulin requirements during pregnancy necessitate short-acting insulins for postprandial control of hyperglycemia. The fast-acting insulin analogue insulin aspart has been tested in a large, randomized trial of pregnant women with Type 1 diabetes and offers benefits in control of postprandial hyperglycemia with a tendency towards fewer episodes of severe hypoglycemia compared with human insulin. Treatment with insulin aspart was associated with a tendency toward fewer fetal losses and preterm deliveries than treatment with human insulin. Insulin aspart could not be detected in the fetal circulation and no increase in insulin antibodies was found. Thus, the use of insulin aspart in pregnancy is regarded safe.