Open AccessMU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION
Author(s) -
Ozaifa Kareem,
Nasir Nisar,
Nahida Tabassum
Publication year - 2017
Publication title -
journal of critical reviews
Language(s) - English
Resource type - Journals
ISSN - 2394-5125
DOI - 10.22159/jcr.2017v4i4.22260
Subject(s) - constipation , medicine , opioid , defecation , chronic constipation , lubiprostone , opioid receptor , irritable bowel syndrome , intensive care medicine , pharmacology , receptor
Constipation disproportionately affects older adults, with a prevalence of 50% in community-dwelling elderly and 74% in nursing-home residents. Loss of mobility, medications, underlying diseases, impaired anorectic sensation, and ignoring calls to defecate are as important as dyssynergic defecation or irritable bowel syndrome in causing constipation. Opioid antagonists not only have well-established indications in the reversal of life-threatening opioid toxicity but also hold considerable promise for other applications in palliative care practice, particularly management of opioid-induced constipation (OIC). This review summarizes the pharmacology of new peripherally acting mu (µ) opioid receptor antagonists (PAMORA).