Open AccessCOMPARISON OF PREGABALIN AND NORTRIPTYLINE ON SLEEP, QUALITY OF LIFE IN POSTHERPETIC NEURALGIA: A PROSPECTIVE, RANDOMISED, OPEN-LABEL, PARALLEL STUDY
Author(s) -
Kanika Khajuria,
Seema Gupta,
Dinesh Kumar,
Dev Raj Dogra,
Vijay Khajuria
Publication year - 2021
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2021v13i6.41244
Subject(s) - pregabalin , nortriptyline , postherpetic neuralgia , medicine , quality of life (healthcare) , clinical global impression , anesthesia , physical therapy , neuropathic pain , alternative medicine , nursing , amitriptyline , pathology , placebo
Objective: Aim of the present study was to compare the effects of pregabalin and nortriptyline on sleep and quality of life in patients of postherpetic neuralgia (PHN).
Methods: The present study was conducted in 48 patients of PHN attending the outpatient department (OPD) of Dermatology, Government Medical College Jammu. Based on inclusion/exclusion criteria patients were randomized into two treatment groups. One group received pregabalin 150 mg/day and the other group was treated with nortriptyline 25 mg/day. The patients were followed up to eight weeks and assessed for Sleep (Medical Outcomes Study sleep scale) and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC) score and Patient Global Impression of Change (PGIC) score were used to evaluate overall clinical improvement.
Results: Both drugs significantly improved all parameters studied (p<0.0001). On comparison, both drugs had similar effects on sleep and quality of life. However, pregabalin was found to be better than nortriptyline at eight weeks on CGIC (p<0.004) and PGIC (p<0.0003) scores.
Conclusion: Both pregabalin and nortriptyline were equally effective in improving sleep and quality of life. Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks.