Open AccessIDENTIFICATION AND QUANTIFICATION OF PHOSPHODIESTERASE-5 INHIBITORS AS ADULTERANTS IN DIETARY SUPPLEMENTS MARKED FOR SEXUAL ENHANCEMENT IN THE LEBANESE MARKET
Author(s) -
Razan Soubra,
Azza A. Gazy,
May Saab,
Marwa K. Al Jamal
Publication year - 2020
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2020v12i3.36527
Subject(s) - tadalafil , sildenafil , medicine , pharmacology , traditional medicine
Objective: Ultraviolet Visible spectrophotometric was adopted to identify and quantify any adulteration with PDE-5 inhibitors (Sildenafil and Tadalafil) in selected dietary supplements used for sexual enhancement in the Lebanese market
Methods: Nine dietary supplements, randomly collected from Lebanese pharmacies, were screened for Sildenafil and Tadalafil using UV-spectrophotometry for both qualitative and quantitative detection.
Results: Tadalafil was detected in one sample at a dose of 59 mg/dosage unit, with the maximal recommended dose being 20 mg. Sildenafil was detected in five samples at doses ranging from 11.7 to 188.2 mg/dosage unit, with the maximal recommended dose being 100 mg.
Conclusion: This study demonstrates that regular analysis of supposed dietary supplements is needed for more effective quality control and health promotion. The method described for the extraction, identification and quantification of Tadalafil and Sildenafil would be useful for regulatory detection of adulterations.