Open AccessFORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE
Author(s) -
Nilesh R. Bhosale,
Nikita S. Kolte
Publication year - 2019
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2019v11i9.34387
Subject(s) - friability , bioavailability , croscarmellose sodium , factorial experiment , chlorpheniramine maleate , camphor , chromatography , materials science , enalapril maleate , chemistry , pharmacology , mathematics , dosage form , medicine , first pass effect , organic chemistry , statistics , radiology , magnesium stearate , enalapril , blood pressure , angiotensin converting enzyme
Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to develop an orally disintegrating tablet of chlorpheneramine maleate with an increase in bioavailability and patient compliance.
Methods: The sublimation technique was used to prepare orally disintegrating tablets. Porous tablet prepared after sublimation of camphor at 60 °C in a hot air oven for 60 min. In the research work, 32full factorial design used to find out the effect of two variables like the amount of Crospovidone and Croscarmellose sodium.
Results: All prepared formulations were analyzed for various parameters. DSC of pure drug and optimized formulation A (9) showed purity of sample and compatibility of all ingredients with each other. In FTIR study of pure drug and optimized formulation A (9) no major shifts were seen. An optimized formulation (A9) was found to have good hardness (3.2 kg/cm2), friability (<1%), disintegration time (26 s), % drug release (99.77 %) within 6 min.
Conclusion: The result obtained showed that orally disintegrating tablet of chlorpheneramine maleate enhances dissolution rate, improves bioavailability which will improve patient compliance.