Open AccessRECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8-NAPHTHYRIDINE DERIVATIVES: A REVIEW
Author(s) -
Vinod Kumar Gurjar,
Dilipkumar Pal
Publication year - 2018
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2018v10i8.27006
Subject(s) - context (archaeology) , antagonism , ionotropic effect , pharmacology , adenosine receptor , biological activity , chemistry , receptor , biology , agonist , in vitro , biochemistry , glutamate receptor , paleontology
The 1,8-naphthyridine derivatives have gained special attention from researchers nowadays on account of their demonstrating a variety of interesting biological activities. A wide range of biological activities establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anti-inflammatory, anticancer, antihypertensive and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer’s disease and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, anti-allergic, antimalarial, gastric antisecretory, anticonvulsant, platelet aggregation inhibition, anti-oxidant, Epidermal Growth Factor Receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibition, adenosine receptor agonist, adrenoceptors antagonism and DNA stabilizing properties. In this review, we present an update of different 1,8-naphthyridine derivatives and discuss the key data available in the context of various biological activities of 1,8-naphthyridine derivatives available from the literature. This may direct future researches in the synthesis of new derivatives of it and exploring this scaffold for modification of existing biological actions as well as evaluation of other possible pharmacological activities.