Open AccessASSOCIATION BETWEEN GENETIC POLYMORPHISMS OF HUMAN CYTOCHROME CYP2E1 AND RISK OF NASOPHARYNGEAL CARCINOMA IN ALGERIA POPULATION
Author(s) -
Djekrif Ghania,
Katia Bendjemana,
Kadri Yahia,
Monia Abdennebi,
Douik Hayat,
Fethi Guémira,
Dalila Satta
Publication year - 2018
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2018v10i4.23389
Subject(s) - nasopharyngeal carcinoma , biology , restriction fragment length polymorphism , genomic dna , genetics , allele , cyp2e1 , nasopharyngeal cancer , population , allele frequency , medicine , gene , microbiology and biotechnology , oncology , gastroenterology , genotype , environmental health , in vitro , microsome , radiation therapy
Objective: The present study was carried out to analyze the relationship between CYP2E1 genetic polymorphism and the risk of developing nasopharyngeal cancer (NPC).Methods: The study involved 100 patients with nasopharyngeal carcinoma, compared with 180 healthy controls. Genomic DNA samples were assayed for restriction fragment length polymorphisms in the CYP2E1 by PCR amplification followed by digestion with RsaI. The frequency comparison between the two groups was determined by the χ(2) test. Results: Our results showed that the distribution of CYP2E1-/-allele frequency was found to be significantly different between controls (22 %) and cancer cases (26%) along with twice increase of the NPC risk in Algeria (OR=2.2, CI 95% [1.02-2.54]). Conclusion: Our results are in line with those found for other populations and subsequent they emphasize the importance of the involvement of this gene in the development of the NPC detoxification process, which exhibited more and more strong association with environmental factors.