Open AccessPREPARATION OF BUDESONIDE-PECTIN BEADS USING THE PERISTALTIC PUMP
Author(s) -
Samir A. Atara,
Moinuddin Soniwala
Publication year - 2018
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2018v10i1.23171
Subject(s) - peristaltic pump , pectin , peristalsis , chemistry , chromatography , dissolution , coacervate , swelling , materials science , composite material , biochemistry , organic chemistry , mechanical engineering , engineering
Objective: To formulate and evaluate budesonide-pectin beads using novel assembly with a peristaltic pump.Methods: The prepared budesonide-pectin dispersion was added to calcium chloride solution with the help of assembly. Provided at least 2 h for hardening and dried at 60 °C for 3 h. Assembly was assembled with the use of a peristaltic pump, polymeric solution reservoir, hose, needle, magnetic stirrer, gelling bath. One side of hose was dipped in pectin solution container and another side was passed through the peristaltic pump and connected to the needle. Peristaltic pump produced pumping of pectin solution through the hose. Needles with variable diameters are available. The gelling bath was kept on magnetic stirrer to keep prepared beads in motion, which helped to provide new surface and sufficient reaction time and helped to avoid agglomeration. There were 10 different batches with different process parameters prepared. Production yield, the diameter of beads, swelling index, and in vitro budesonide dissolution in phosphate buffer pH 7.4 after 5 h was determined.Results: There was a significant difference between selection of process parameter among the batches (p = 0.049, q = 6.11). As nozzle diameter was increased, percentage yield was decreased (p = 0.0038, q>5.98). However, if hardening time was decreased percentage release was increased (p = 0.0361, q>5.98).Conclusion: The novel assembly for bead generation had developed a uniform, spherical shaped, and smooth surfaced beads.