SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF POTASSIUM CIS-DIAQUA-BIS (OXALATO) CHROMATE (III) WITH LEVODOPA AND CARBIDOPA

Objective: These studies focus on the interaction between two clinically active antiparkinsonian drugs L-dopa (L) and carbidopa (C) with the cis-[Cr(C2O4)2(H2O)2]-and evaluation of the synthesized product from a coordination chemistry aspect with respect to the possibility of its antioxidant activity and its therapeutic application in the treatment of Parkinson disease.Methods: The resulting synthesized complexes were characterized by UV-VIS and FTIR spectroscopy. Evaluation of antioxidant activities of this cis-[Cr(C2O4)2(H2O)2]--L-dopa(ML), cis-[Cr(C2O4)2(H2O)2]--carbidopa(MC) and standard butylated hydroxytoluene (BHT) were carried out by using 1,1-diphenyl-1-picrylhydrazyl free radical (DPPH), 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cations and hydrogen peroxide method.Results: The results of spectral analysis of the synthesized products indicate that complexes have a Cr(III) ion coordinated via the carboxylic and amino group. In the reduction of radical DPPH· and the formation of radical monocation ABTS·+the ability to scavenge radical was measured in these experiments by the discoloration of the solution. However, in hydrogen peroxide method, the increased in absorbance showing its scavenging potential. The scavenging capacity of the test compounds and standard on the DPPH, ABTS·+, H2O2 decreased in the order BHT>ML>MC>C>L which were 98.4, 96.4, 86.4, 68.3, 49.7% for DPPH, BHT>ML>L>MC>C which were 99.3, 96.9, 96.3,66.6, 53.4% for ABTS·+, BHT>ML>MC>L>C which were 68.8%, 52.4%, 49.6%, 43.1% and 37.7% for H2O2 at the concentration of 50 µg/ml, respectively.Conclusion: The experimental findings showed that cis-[Cr(C2O4)2(H2O)2]--levodopa and cis-[Cr(C2O4)2(H2O)2]--carbidopa are having higher antioxidant potential than Levodopa and carbidopa although not superior to that of standard compound.