Open AccessNANOCRYSTAL SUSPENSION OF CEFIXIME TRIHYDRATE PREPARATION BY HIGH-PRESSURE HOMOGENIZATION FORMULATION DESIGN USING 23 FACTORIAL DESIGN
Author(s) -
Rajveer Bhaskar,
Prakash H. Patil
Publication year - 2017
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2017v9i9.19319
Subject(s) - zeta potential , permeation , differential scanning calorimetry , dispersity , particle size , materials science , bioavailability , factorial experiment , solubility , chemical engineering , fourier transform infrared spectroscopy , nanocrystal , nanoparticle , chromatography , chemistry , nanotechnology , organic chemistry , polymer chemistry , mathematics , physics , membrane , thermodynamics , bioinformatics , biochemistry , statistics , biology , engineering
Objective: In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing increased solubility and stability with their nanoscopic size and thus developing the formulation of enhanced bioavailability potential.Methods: Nanocrystal suspensions were prepared by high-pressure homogenization technique using PVP K-30 as a stabilizer and evaluated for particle size, polydispersity index, zeta potential, permeation and drug release.Results: Particles of average size 143.5 nm having a polydispersity index of 0.269 were produced. Zeta potential was found to be −36.6 mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and Fourier transform infrared spectroscopy studies. Optimized formulation showed 89.79 % and 88.38% drug lease and permeation respectively.Conclusion: The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nano crystal formulation.