Open AccessBIOLOGICAL AND DOCKING STUDIES OF NOVEL AROYLHYDRAZONES
Author(s) -
J. Manjula,
R. Maheswari
Publication year - 2017
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2017v9i5.10862
Subject(s) - inha , docking (animal) , mycobacterium tuberculosis , chemistry , protein data bank (rcsb pdb) , antifungal , isoniazid , stereochemistry , antibacterial activity , combinatorial chemistry , staphylococcus aureus , in silico , biochemistry , tuberculosis , microbiology and biotechnology , bacteria , biology , medicine , genetics , nursing , pathology , gene
Objective: Novel aroylhydrazone schiff bases were synthesized and were screened for their biological activities.Methods: Using HCl as a catalyst, all the compounds were synthesized at room temperature and were characterized by IR and NMR techniques. The synthesized Schiff bases were screened for antibacterial, antifungal activities. In silico molecular docking, method was performed to study their anti-tuberculosis activity against enoyl acyl carrier protein reductase (InhA) from Mycobacterium tuberculosis (PDB id: 2NSD). Results: Compound P1 showed good antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacterial strains and compound J1 showed good antifungal activity against A. niger. Molecular docking results reveal that compound B1 made two numbers of electrostatic interactions with 2NSD with more negative C docker interaction value. This indicated that the compound B1 was more active with minimum binding potential which is comparable with that of standard compound isoniazid.Conclusion: Aroylhydrazones having good biologically activities compared to that of standards were prepared.