Open AccessAMELIORATIVE EFFECT OF CAROB AQUEOUS EXTRACT ON WATER PIPE SMOKE INDUCED-TOXICITY IN ADULT MALE ALBINO RATS
Author(s) -
Mona Abdel Rahman,
Fatma Elzahraa H. Salem,
Amira A. Bauomy,
Mona Khalifa
Publication year - 2016
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2017v9i1.15470
Subject(s) - chemistry , alkaline phosphatase , toxicity , zoology , urea , creatinine , albumin , medicine , endocrinology , biochemistry , biology , enzyme , organic chemistry
Objective: The aim of the present study was to investigate the daily effect of pre and post treatment of carob aqueous extract (600 mg/kg b. wt.); on rats exposed to were exposed to water pipe smoke (10 mg/kg; 15 minutes) for 2, 4, 6 and 8 w. Methods: Rats were divided into 6 groups; 1 st group was served as a control. Rats of the 2 nd group were administered amiodarone (an antiarrhythmic medication used as a model for lung toxicity) at a dose level of 30 mg/kg. The rats of 3 rd and 4 th groups were exposed to water pipe smoke and treated with carob extract respectively. However, the two remaining groups (5 th and 6 th ) were the pre-and post-treatment groups with carob extract respectively. Results: Amiodarone and water pipe smoke induced a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP); on the contrary, induced a significant decrease in serum total protein and albumin. In addition; serum creatinine and urea showed a significant increase; as well as; amiodarone and water pipe smoke increased the oxidative stress (malondialdehyde/glutathione; MDA/GSH) in lung tissue homogenate. While; carob extract gavage showed protective and curative effects in liver and kidney functions; in addition; it decreased MDA level and increased GSH level significantly. Conclusion: Finally, we can conclude that the carob aqueous extract treatment revealed ameliorative effects on rats were exposed to water pipe smoke.