Open AccessENHANCEMENT OF LORNOXICAM SOLUBILITY BY INCLUSION COMPLEXATION WITH CYCLODEXTRIN: PREPARATION AND CHARACTERIZATION
Author(s) -
Shahira F. El-Menshawe,
Essam Eissa,
Adel A. Ali,
Ahmed A. Abderhman
Publication year - 2016
Publication title -
international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2017v9i1.14848
Subject(s) - solubility , differential scanning calorimetry , lornoxicam , cyclodextrin , chemistry , bioavailability , nuclear chemistry , fourier transform infrared spectroscopy , chromatography , organic chemistry , analgesic , chemical engineering , pharmacology , medicine , physics , engineering , thermodynamics
Objective: Lornoxicam is a potent anti-inflammatory drug which has analgesic and antipyretic properties. It is water-insoluble powder. The inclusion complexes of lornoxicam (LOR) with β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were prepared and characterised in order to improve the solubility of the drug and enhance its bioavailability. Methods: Complexes were prepared by physical mixing and freeze-drying in three different drug/polymer ratios (1:1, 1:2 and 3:2). The solid complexes were characterised through differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray diffraction, nuclear magnetic resonance (NMR) spectroscopy, and Fourier transformed infrared (FTIR) spectroscopy. Results: The data showed that LOR may be complexed with cyclodextrin (CD) forming soluble complexes. The lyophilized 1:2 LOR/HPCD complex is the most soluble. Conclusion: Solubility increases with lyophilization than with physical mixing and by the use of HPCD than βCD in complexation.
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