Open AccessA STUDY OF THE HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF WHOLE PLANT EXTRACTS OF IPOMOEA AQUATICA FORK IN EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN RABBITS
Author(s) -
Sahid Aziz,
Kalpana Gohain
Publication year - 2016
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2016v8i10.14059
Subject(s) - hyperlipidemia , triglyceride , malondialdehyde , chemistry , antioxidant , ipomoea aquatica , superoxide dismutase , cholesterol , high density lipoprotein , zoology , biochemistry , endocrinology , biology , diabetes mellitus , spinach
Objective: The aim of the study has been to investigate the possible hypolipidemic and antioxidant properties of the whole plant extract of Ipomoea aquatica in experimentally induced hyperlipidemia in rabbits. Methods: Ethanolic extract of I. aquatica whole plant (EEIAWP) was prepared by percolation method. The extract was evaluated for hypolipidemic and antioxidant activities using 400 mg/kg body weight per day in a high fat diet induced hyperlipidemia in rabbits. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests and compared to the normal control, experimental control and the standard drug (atorvastatin 2.1 mg/kg body weight per day) groups. The results were expressed as mean±standard error of mean (SEM). Values with p <0.05 were considered significant. Results: Oral administration of EEIAWP in the test group showed a significant reduction in the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and a significant increase in the high-density lipoprotein cholesterol (HDL-C) when compared to the experimental control group. There were also significantly elevated catalase and superoxide dismutase (SOD) activities and significantly lower malondialdehyde (MDA) levels in the test group compared to the experimental group. Similar results were also found in the standard drug group. Conclusion: The results of our experiment demonstrated that EEIAWP possesses significant antihyperlipidemic and antioxidant activities and hence could be a potential source of medication as an adjuvant to the existing therapy for treatment of dyslipidemia.