Open AccessSYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION
Author(s) -
Vaibhav Sharma,
Dinesh Kumar Mehta,
Rina Das,
Preet Kawal Kaur
Publication year - 2016
Publication title -
international journal of pharmacy and pharmaceutical sciences/international journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2656-0097
pISSN - 0975-1491
DOI - 10.22159/ijpps.2016.v8i9.11269
Subject(s) - chemistry , schiff base , aspergillus niger , benzoic acid , antimicrobial , escherichia coli , stereochemistry , antibacterial activity , bacteria , nuclear chemistry , biochemistry , organic chemistry , biology , genetics , gene
Objective: This work involves the synthesis of some novel schiff base derivatives synthesized from p- amino benzoic acid. Methods: A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, 1 H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria ( Staphylococcus aureus and Streptococcus pneumoniae) and Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa) and anti-fungal activity against ( Candida albicans and Aspergillus niger). Results: Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity. Conclusion: The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes.