Open AccessTREATMENT OF EXTRA-VIRGIN OLIVE OIL ON ETHANOL- AND BENZENE-INDUCED ACINAR CELLS DAMAGE IN ADULT WISTAR RATS
Author(s) -
Adetunji Opeyemi Adebola,
ADERUPOKO IDAYAT TOMILOLA,
ADETUNJI OLUWASEYI ADEGOKE,
OGUNBIYI BABAFEMI TOSIN,
Adetunji Iyabode Toyin,
NWOBI NNENNA LINDA,
Ogunbiyi Olubunmi Esther,
NWOBI JOSEPH CHIGBOGU,
BEJIDE AYODELE ROLAND
Publication year - 2022
Publication title -
innovare journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2321-4406
DOI - 10.22159/ijms.2022.v10i2.44088
Subject(s) - ethanol , benzene , chemistry , olive oil , amylase , placebo , medicine , biochemistry , food science , enzyme , organic chemistry , pathology , alternative medicine
Objective: The study is focused on the effect ethanol and benzene on the acinar cells and extra- virgin olive oil (EVOO) as an ameliorative agent.Methods: Forty-eight Wistar rats were divided into eight groups of six animals per group: (1) Control group (a placebo of water), (2) EVOO, (3) 25% ethanol, (4) 200 mg/kg benzene, (5) 25% ethanol+200 mg/kg benzene (EB), (6) 25% ethanol+EVOO (EO), (7) 200 mg/kg benzene+EVOO (BO), and (8) 25% ethanol+200 mg/kg benzene+EVOO (EBO). The ethanol, benzene, and EVOO were administered orally.Results: All the treatment groups lost body weight except Groups 1 and 2. The histology of the pancreas showed significant (p≤0.05) damage to the acinar cells of groups exposed to 25% ethanol, 200 mg/kg benzene, and EB when compared to the control, EVOO, EO, BO, and EBO. The enzymatic activities of amylase and lipase evaluated showed significant (p≤0.05) decrease in EO and BO as compared to 25% ethanol, 200 mg/kg benzene, and EB-treated groups.Conclusion: There was an elevated glucose concentration in 25% ethanol and EBO as compared to control and EVOO has anti-inflammatory potential across the ameliorated groups.