Open AccessCONDUCTOMETRIC DETERMINATION OF LOSARTAN POTASSIUM USING PHOSPHOTUNGSTIC ACID, BROMOCRESOL PURPLE, MERCURY (II) CHLORIDE, AND CUPRIC CHLORIDE AS REAGENTS
Author(s) -
Afaf A. Abdelmonem,
Eman A. Bahgat
Publication year - 2019
Publication title -
innovare journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2321-4406
DOI - 10.22159/ijms.2019.v7i1.30585
Subject(s) - phosphotungstic acid , chemistry , titration , conductometry , chloride , reagent , bromocresol purple , bromocresol green , chromatography , mercury (programming language) , potassium , inorganic chemistry , biochemistry , organic chemistry , computer science , programming language , catalysis
Objectives: In the current study a simple and precise four conductometric methods were introduced for determination of Losartan Potassium (LK) in pure form and tablets.
Methods: Method A is based on titration of LK using phosphotungstic acid, method B is based on titration of LK using bromocresol purple dye, method C is based on titration of LK using mercury (II) chloride, and method D is based on titration of LK using cupric chloride.
Results: LK was found to be linear in the concentration range of 3–20 mg/mL for all methods except for method C, the concentration range was 1–12 mg/mL. The obtained percentage recoveries for the four methods ranged from 99.69% to 100.53%; the relative standard deviation values were not exceeding two for all methods.
Conclusion: The suggested methods were successfully applied for the determination of LK in tablets, with results in close agreement at 95% confidence level with those obtained using the reference spectrophotometric method.