Open AccessEXPERIMENTAL STUDY ON SWISS WHITE MICE TO EVALUATE THE ANTIANXIETY EFFECT OF COMMON WILD FIG EXTRACT (FICUS THONNINGII)
Author(s) -
Aduema Wadioni
Publication year - 2019
Publication title -
innovare journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2321-4406
DOI - 10.22159/ijms.2019.v7i1.29357
Subject(s) - traditional medicine , saline , analysis of variance , positive control , medicine , anxiety , negative control , elevated plus maze , physiological saline , pharmacology , toxicology , anesthesia , biology , psychiatry
Objective: Since prehistoric times, man has relied on herbal plants as a source of medicine in curing various ailments. This study was carried out to assess the antianxiety-like effect of the ethanol extract of wild fig (Ficus thonningii) in Swiss white (CD-1) mice.
Methods: Thirty Swiss mice were randomly divided into three groups (1–3) (n=10). Group 1 (control) was administered normal rat fed and saline, while Group 2 (low dose) and Group 3 (high dose) were administered 10 mg/kg w/w and 20 mg/kg w/w of the plant extract, respectively. The elevated plus maze was used to assess anxiety-related behaviors.
Results: Data were analyzed using the statistical tools (one-way ANOVA and student t-test). Results revealed anxiety-like behavior in the low- and high-dose-treated mice when compared to the control.
Conclusion: Therefore, administration of F. thonningii reduced an anxiety-like behavior in mice.