Open AccessSYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SILVER (I) MEBENDAZOLE COMPLEXES
Author(s) -
Olufunso O. Abosede,
LOVETH E. EZEGWU
Publication year - 2022
Publication title -
international journal of chemistry research
Language(s) - English
Resource type - Journals
ISSN - 0976-5689
DOI - 10.22159/ijcr.2022v6i2.203
Subject(s) - mebendazole , chemistry , antimicrobial , moiety , benzimidazole , proteus mirabilis , imidazole , silver nitrate , phenanthroline , nuclear chemistry , aqueous solution , solubility , combinatorial chemistry , organic chemistry , escherichia coli , biochemistry , biology , gene , ecology
Objective: The aim of this research work is to synthesize silver-mebendazole complexes with imidazole (imi), 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen) as secondary ligands that will be active and effective against microbes.Methods: Environmentally friendly techniques were employed to synthesize the new complexes by reacting silver nitrate and ligands in water and at ambient conditions. The formed complexes were isolated and dried at ambient conditions and characterized by UV and FTIR spectroscopies; the physicochemical and antimicrobial properties of the complexes against Proteus mirabilis and Salmonella typhi were also tested by agar well diffusion method.Results: Spectroscopic studies confirmed the formation of the complexes. In the newly synthesized complexes, silver is coordinated by N of the imidazole moiety of mebendazole as well as N atoms of imidazole, 2,2-bipyridine and 1,10-phenanthroline. The complexes are stable and possess low aqueous solubility. Antimicrobial analyses revealed that they were active against the tested organisms with antibacterial activities higher than the parent drug, mebendazole.Conclusion: The newly synthesized complexes were stable and the results show their antimicrobial potential. The resultant antimicrobial activity of the complexes is as a result of synergistic activities of silver and the ligands.