Open AccessSYNTHESIS AND CHARACTERIZATION OF BOC-PROTECTED THIO-1,3,4-OXADIAZOL-2-YL DERIVATIVES
Author(s) -
S. Syed Shafi,
R. Rajesh,
Soundararasu Senthilkumar
Publication year - 2021
Publication title -
international journal of chemistry research
Language(s) - English
Resource type - Journals
ISSN - 0976-5689
DOI - 10.22159/ijcr.2021v5i3.169
Subject(s) - phenylacetate , chemistry , thio , thermal stability , alcohol , hydrazine (antidepressant) , organic chemistry , amino acid , nuclear chemistry , chromatography , biochemistry
Objective: The objective of this work is to synthesis thio-1,3,4-oxadiazol-2-yl derivatives for industrial applications.Methods: The synthesis was done by the reaction of (S)-2-amino-2-phenylacetic acid with ethanol-derived ethyl (S)-2-amino-2-phenylacetate. The reaction of ethyl (S)-2-amino-2-phenylacetate with Boc anhydride and hydrazine produces ethyl (S)-2-((tert-butoxycarbonyl)amino)-2-phenylacetate. The intermediate 5-alkyl amino-1,3,4-oxadiazole-2-thiols have been isolated as stable compounds.Results: To study the characteristics of these compounds, they are subjected to 1HNMR, 13CNMR, and IR. These studies examine the chemical structure of synthesized compounds. The mass of the novel compounds was established with the help of the LCMS test. The structural and optical properties were examined by the powder XRD and photoluminescence spectrum respectively.Conclusion: The sharp intense peak in the powder XRD indicates the crystal nature of the sample. The values obtained from the LCMS test indicate that the compounds have good thermal stability. The absorption peak at 358 nm in the PL spectrum indicates that the sample can be used in photoelectronic devices.