HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB | Zendy

Santosh Karajgi | Zendy; Shripad Potadar | Zendy

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HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB

Author(s) -

Santosh Karajgi,

Shripad Potadar

Publication year - 2020

Publication title -

international journal of current pharmaceutical research

Language(s) - English

Resource type - Journals

ISSN - 0975-7066

DOI - 10.22159/ijcpr.2020v12i4.39082

Subject(s) - pazopanib , chemistry , solubility , chromatography , absorption (acoustics) , pharmacology , materials science , medicine , organic chemistry , oncology , renal cell carcinoma , sunitinib , composite material

Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water. Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model. Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration. Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.

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