Open AccessHYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB
Author(s) -
Santosh Karajgi,
Shripad Potadar
Publication year - 2020
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2020v12i4.39082
Subject(s) - pazopanib , chemistry , solubility , chromatography , absorption (acoustics) , pharmacology , materials science , medicine , organic chemistry , oncology , renal cell carcinoma , sunitinib , composite material
Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water.
Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model.
Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration.
Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.