Open AccessANTIHYPERGLYCEMIC ACTIVITY OF IMPERATA CYLINDRICA ROOT METHANOL EXTRACT IN RATS
Author(s) -
Ruslin Ruslin,
Vica Aspadiah,
Diah Dhianawaty
Publication year - 2020
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2020v12i3.38324
Subject(s) - imperata , chemistry , methanol , absorption (acoustics) , sodium , positive control , small intestine , chromatography , biochemistry , traditional medicine , botany , biology , medicine , physics , organic chemistry , acoustics
Objective: This study aims to evaluate the inhibitory activity of Imperatacylindrica root methanol extract on glucose absorption level in intestine of male Wistar strain rats at a dose of 90 mg/kg-bw, which is a dose having antihypertensive activity.
Methods: Extract inhibitory activity on the glucose absorption level in the intestine of the rats followed Soedigdo-Marsongkohadi method. Glucose absorption level was measured from a mixture of 30 mmol glucose in 0.9 % sodium chloride solution as the control solution and a mixture of the extract at the dose of 90 mg/kg-bw in another control solution as the tested solution
Results: The result showed that the extract at the dose of 90 mg/kg-bw had significant activity (p<0.05) to decrease the glucose absorption level in the intestine of the rats.
Conclusion: I. cylindrica root methanol extract at the dose of 90 mg/kg-bw had a significant activity to inhibit the glucose absorption level in the intestine of the rats. Thereby, the extract at the dose of 90 mg/kg-bw had antihyperglycemic activity.