Open AccessULTRASOUND ASSISTED GREEN SYNTHESIS OF 2-FURAN-2-YL-4H-CHROMEN-4-ONES FROM CHALCONES
Author(s) -
Gopal K. Kakade,
Suresh G. Vedpathak
Publication year - 2020
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2020v12i3.38312
Subject(s) - furan , chemistry , dimethyl sulfoxide , iodine , ultrasound , yield (engineering) , organic chemistry , combinatorial chemistry , nuclear chemistry , materials science , physics , acoustics , metallurgy
Objective: To report the ultrasound-assisted synthesis of some bioactive 2-furan-2-yl-4H-chromen-4-one derivatives
Methods: Oxidative cyclization of chalcones using iodine in dimethyl sulfoxide for the synthesis.
Results: Some bioactive 2-furan-2-yl-4H-chromen-4-one derivatives were synthesized from corresponding chalcones in the presence of iodine in dimethyl sulfoxide under ultrasound irradiation at ambient reaction conditions.
Conclusion: The use of ultrasound irradiation gave the advantages of higher yields, lower reaction time and simplicity compared to conventional methods for the synthesis of 2-furan-2-yl-4H-chromen-4-one derivatives.