DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TADALAFIL IN BULK AND FORMULATION | Zendy

Shrishail M Ghurghure | Zendy; MANISHA S. DYAWARKONDA | Zendy; Sachin Yanjane | Zendy

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DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TADALAFIL IN BULK AND FORMULATION

Author(s) -

Shrishail M Ghurghure,

MANISHA S. DYAWARKONDA,

Sachin Yanjane

Publication year - 2020

Publication title -

international journal of current pharmaceutical research

Language(s) - English

Resource type - Journals

ISSN - 0975-7066

DOI - 10.22159/ijcpr.2020v12i3.38310

Subject(s) - tadalafil , linearity , dimethyl sulfoxide , chemistry , robustness (evolution) , chromatography , linear regression , analytical chemistry (journal) , mathematics , statistics , organic chemistry , engineering , electronic engineering , medicine , biochemistry , sildenafil , gene

Objective: A new simple, sensitive, precise and reproducible spectroscopic method was developed for the determination of Tadalafil in Pharmaceutical formulation with Dimethyl Sulfoxide. Methods: The UV spectrum of Tadalafil in Dimethyl sulfoxide (DMSO) showed λ max at 285.6 nm. Beer’s law is valid in the concentration range of 10-60µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method was demonstrated excellent linearity over the range of 10-60µg/ml with regression equation y= 0.0337x-0.1343 and regression correlation R2= 0.998. Moreover, the method was found to be highly sensitive with LOD (2.44µg/ml) and LOQ (7.40µg/ml). Conclusion: Based on results, the proposed method can be successfully applied for assay of Tadalafil in various pharmaceutical dosage forms.

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