Open AccessRADIOPROTECTION OF ALOE VERA AGAINST BIOCHEMICAL ALTERATIONS IN SWISS ALBINO MICE
Author(s) -
Priyanka Dadupanthi
Publication year - 2018
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2018v10i3.27339
Subject(s) - aloe vera , antioxidant , chemistry , glutathione , irradiation , radical , body weight , pharmacology , traditional medicine , biochemistry , biology , medicine , enzyme , nuclear physics , physics
Objective: In this study, radioprotection against radiation-induced hepatic damage in Swiss Albino Mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals.Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5,10 and 20 after irradiation to evaluate the radio modulator effect in terms of LPO and GSH.Results: Radiation treatment showed a decrease in GSH content and an increase of LPO in control set animals, however, the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO but values remained below normal.Conclusion: The result of present study suggests that Aloe vera has a radioprotective effect due to their antioxidant and radical scavenging activity.