Open AccessANTICONVULSANT EFFECTS OF NIFEDIPINE ON MES INDUCED SEIZURES
Author(s) -
Jain Raina,
Ashish Jain,
Prashant Wadagvalkar
Publication year - 2018
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2018v10i3.27334
Subject(s) - nifedipine , anticonvulsant , epilepsy , pharmacology , chemistry , anesthesia , convulsion , medicine , calcium , psychiatry
Objective: To evaluate the anticonvulsant activity of Nifedipine against MES induced seizures.Methods: The study was induced by techno electroconvulsometer. The animals were treated with Nifedipine (100 μg/100 g i. p. and 200 μg/100 g i. p.) and MES was induced 2 h after the administration of the drug, and duration of various phases was noted. Duration of THLE was taken as an index for antiepileptic activity.Results: Nifedipine when administered in a dose of 100 μg/100 g ip, did not produce any changes in any phases of the MES induced seizure. But in a dose of 200 μg/100 g ip, it significantly reduced the duration of THLE.Conclusion: Nifedipine has a significant action against MES induced seizures suggesting an important role of CCBs as future, promising antiepileptic drug.