Open AccessEVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES
Author(s) -
M Jalaiah,
R Sarvanan,
C H Gowtham,
Y Vinay,
Y Akhila
Publication year - 2017
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2017v9i6.23424
Subject(s) - allium , lactate dehydrogenase , chemistry , creatinine , cholesterol , liliaceae , creatine kinase , traditional medicine , botany , biochemistry , biology , enzyme , medicine
Objective: The present work deals with the study of the ethanolic extract of fruits of Allium cepa aerial leaves for cardioprotective activity.Methods: Cardioprotective activity of the ethanolic extract of aerial leaves of Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have showed infiltration of inflammatory cells and lacking of continuity in muscle fiber was suggesting an irreversible cell injury.Conclusion: Animals treated with ethanolic extract of Allium cepa aerial leaves showed less degenerative changes compared to isoproterenol-treated animals.