Open AccessFORMULATION AND IN VITROEVALUATION OF FLOATING TABLETS OF CEFPODOXIME PROXETIL
Author(s) -
Bharat W. Tekade,
Umesh T. Jadhao,
Shruti G. Patil,
Varsha Patil
Publication year - 2017
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2017v9i6.23422
Subject(s) - friability , chromatography , chemistry , cefpodoxime , guar gum , mathematics , high performance liquid chromatography , polymer , antibacterial agent , food science , organic chemistry , biochemistry , antibiotics , ethyl cellulose
Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.