EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY AND HPTLC ANALYSIS OF PLANT PHYLLANTHUS FRATERNUS | Zendy

Biresh Kumar Sarkar | Zendy; Ravi Kumar | Zendy; Reeta | Zendy; Subash Chandra Verma | Zendy; Shashi Pal | Zendy; Maddi Ramaiah | Zendy; C. Murali Krishna | Zendy; Joginder Singh | Zendy

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EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY AND HPTLC ANALYSIS OF PLANT PHYLLANTHUS FRATERNUS

Author(s) -

Biresh Kumar Sarkar,

Ravi Kumar,

Reeta,

Subash Chandra Verma,

Shashi Pal,

Maddi Ramaiah,

C. Murali Krishna,

Joginder Singh

Publication year - 2017

Publication title -

international journal of current pharmaceutical research

Language(s) - English

Resource type - Journals

ISSN - 0975-7066

DOI - 10.22159/ijcpr.2017v9i5.22328

Subject(s) - anti inflammatory , in vitro , chemistry , lipoxygenase , cyclooxygenase , traditional medicine , phyllanthus , chromatography , biochemistry , enzyme , pharmacology , biology , medicine

Objective: The present investigation evaluated in vitro anti-inflammatory activity of Phyllanthus fraternus. Inhibition of Cyclooxygenase and 5-lipoxygenase was performed along with protein denaturation.Methods: Alcoholic extract of plant was subjected to in vitro anti-inflammatory activity and HPTLC analysis.Results: The results of anti-inflammatory activity showed significant inhibition in Cyclooxygenase and 5-lipoxygenase assay, extract also showed more than 70 % inhibition in protein denaturation method. HPTLC of plant materials was also performed; spots of alkaloids were recorded.Conclusion: Different alkaloids were spotted in chromatographic analysis and study suggested that anti-inflammatory activity of Phyllanthus fraternus may be due to the presence of alkaloids.Â

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