Open AccessSYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES
Author(s) -
Sarath Sasikumar,
M Haripriya,
T Anjali
Publication year - 2016
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2016v8i4.15281
Subject(s) - diclofenac sodium , antibacterial activity , chemistry , staphylococcus aureus , anti inflammatory , escherichia coli , drug , nuclear chemistry , combinatorial chemistry , melting point , pharmacology , organic chemistry , chromatography , biochemistry , bacteria , medicine , biology , genetics , gene
Objective: A series of 1, 2-Benzisoxazole derivatives were synthesized and characterized by various analytical techniques like Melting point, Rf, FTIR, and NMR spectra.Methods: Structures of the compounds were elucidated and evaluated for anti-inflammatory activity by HRBC membrane stabilization method, antibacterial activity against Escherichia coli and Staphylococcus aureus by cup plate method.Results: The compounds 4a and 4e showed good anti-inflammatory activity compared with standard drug Diclofenac sodium and compounds 4b and 4d showed good antibacterial activity on compared with standard drug Gentamycin.Conclusion: These compounds may serve as future leads for anti-inflammatory and antibacterial drug discovery.