Open AccessIN VITRO ANTICANCER ACTIVITY OF 5’ FLUO URACIL COATED CHITOSAN NANOPARTICLE
Author(s) -
Chittakath Shaima,
Puthamohan Vinayaga Moorthi,
Shaheen Naser Kutty
Publication year - 2016
Publication title -
international journal of current pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 0975-7066
DOI - 10.22159/ijcpr.2016v8i4.15267
Subject(s) - chitosan , in vitro , hep g2 , chemistry , ic50 , nanoparticle , anticancer drug , liver cancer , scanning electron microscope , uracil , cell culture , nuclear chemistry , fluorouracil , pharmacology , drug , nanotechnology , cancer , biochemistry , materials science , biology , dna , genetics , composite material
Objective: 5’ Fluorouracil (5’FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line.Methods: The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM).Results: The 5FCN revealed an IC50 value of 49.50 µl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment.Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model.