Open AccessMELOXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM: FORMULATION AND RELEASE KINETICS ANALYSIS
Author(s) -
Sadina Aulia,
Lina Winarti,
Yudi Wicaksono
Publication year - 2021
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2021.v13s4.43856
Subject(s) - meloxicam , pulmonary surfactant , chemistry , polyethylene glycol , chromatography , peg ratio , peg 400 , dissolution , drug delivery , bioavailability , pharmacology , medicine , organic chemistry , biochemistry , finance , economics
Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze the release kinetics of meloxicam SNEDDS and non-SNEDDS using DDSolver.
Methods: Meloxicam SNEDDS was prepared using sunflower seed oil, Cremophor RH 40 as a surfactant, and polyethylene glycol (PEG) 400 as a co-surfactant.
Results: The best formula obtained subjected to the in vitro dissolution study was analyzed using DDSolver. The study shows one selected formula consists of 10% sunflower seed oil, 70% cremophor RH 40, and 20% PEG 400 with a 20.5 nm±12 nm droplet size. The dissolution study showed that SNEDDS could significantly increase the meloxicam release compared to the non-SNEDDS formulation. The kinetics of meloxicam release from SNEDDS formulations follow the Weibull release model (β = 1.00).
Conclusion: This study concludes that SNEDDS best prepared in sunflower seeds oil: Chremophor RH 40: PEG 400 ratio of 1: 7: 2 and has the potency to increase the solubility and dissolution of meloxicam.