Open AccessANTIPYRETIC ACTIVITY OF CENTELLA (CENTELLA ASIATICA (L.) URBAN) HERB IN VACCINE INDUCED MICE
Author(s) -
Nyi Mekar Saptarini,
Endah Kartikawati
Publication year - 2021
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2021.v13s3.16
Subject(s) - centella , antipyretic , herb , traditional medicine , medicine , pharmacology , medicinal herbs , analgesic
Objective: This study aimed to determine the antipyretic activity of the infusion of centella (Centella asiatica (L.) Urban) herb, based on empirically usage of Indonesian people.
Methods: Antipyretic activity assay was conducted to Swiss-Webster mice, which induced by diphtheria-pertussis-tetanus (DPT) vaccine with paracetamol as positive control.
Results: Centella herb was contained tannins, flavonoids, monoterpenoids, sesquiterpenoids, triterpenoids, steroids, and saponins. The antipyretic activity of centella infusion has a ratio 1:44.6, compare to paracetamol.
Conclusion: Antipyretic activity of centella herbs was predicted due to its secondary metabolites.