Open AccessCHEMICAL REACTION KINETICS OF 1,5-BIS (3'-ETHOXY-4'-HYDROXYPHENYL)-1,4–PENTADIENT-3–ONE SYNTHESIS WITH FOOD GRADE RAW MATERIAL
Author(s) -
Esti Mumpuni,
Esti Mulatsari,
Agus Puwanggana,
Sola Fide Vicy
Publication year - 2021
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2021.v13s2.13
Subject(s) - chemistry , reaction rate constant , ethyl acetoacetate , acetone , vanillin , reaction rate , order of reaction , alkoxy group , ethyl acetate , chemical kinetics , kinetics , nuclear chemistry , organic chemistry , catalysis , alkyl , physics , quantum mechanics
Objective: This research aims to develop the 1,5-bis (3'-ethoxy-4'-hydroxyphenyl)-1,4-pentadient-3-one (EHP) synthesis method from ethyl vanilin with food-grade quality and determines the order reaction and formation reaction rate constant of EHP.
Methods: Synthesis of the EHP was carried out by reflux the starting material, ethyl vanillin (food grade) of various weights, acetone and hydrochloric acid as catalysts. The reflux results are then condensed for two days at cold temperatures. Determination of the reaction order and reaction rate constants are carried out by the graph method based on the reduction in the concentration of ethyl vanilin, which reacts with acetone each time unit.
Results: The results showed the formation of EHP, which was synthesized by starting material of ethyl vanilin food grade 4 and 8 grams following pseudo-first-order reaction kinetics with reaction rate constants respectively 0,0116/minute and 0,005/minute. The formation of EHP, which was synthesized by starting material ethyl vanilin food grade 16 and 18 grams following zero-order reaction kinetics with reaction rate constants respectively 0,1451 mg/ml minute and 0,248 mg/ml minute.
Conclusion: The synthesis of EHP from ethyl vanilin with food-grade quality has been success develop. The order reaction kinetics are different in the different mass of ethyl vanillin used.