Open AccessKLUTUK BANANA (MUSA BALBISIANA COLLA) PEEL FRACTIONS: ANTIOXIDANT AND ANTIHYPERGLYCEMIC POTENTIAL
Author(s) -
Tita Nofianti,
Ahmad Muhtadi,
Irda Fidrianny,
Ai Samrotul Fuadah,
Vera Nurviana,
Ruswanto Ruswanto
Publication year - 2021
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2021.v13s2.01
Subject(s) - ethyl acetate , antioxidant , chemistry , dpph , banana peel , extraction (chemistry) , food science , fraction (chemistry) , fractionation , chromatography , biochemistry
Objective: The purposes of this research were the antihyperglycemic and antioxidant determination of klutuk banana peel fractions through the oral glucose tolerance test (OGTT) and DPPH (2,2-diphenyl-1-picrylhydrazyl) methods, respectively.
Methods: Klutuk banana peel was extracted by reflux method and followed by fractionation using n-hexane and ethyl acetate solvents by liquid-liquid extraction method. The statistical analysis used by one-way ANOVA and post hoc Tukey.
Results: The results of OGTT showed that ethyl acetate fraction of klutuk banana peel 14.5 mg/kg bw demonstrated higher activity to decrease blood glucose level compared to the other groups as much-32%,-49%,-47% and-40% at min 30, 60, 90 and 120, respectively. The IC50 of ethyl acetate fraction of klutuk banana peel was 0.3708 µg/ml, and its antioxidant activity index (AAI) 40.45.
Conclusion: The ethyl acetate fraction of klutuk peel presented very strong antioxidant and antihyperglycemic activity.