IMPROVEMENT OF SIMVASTATIN DISSOLUTION RATE USING DERIVATIVE NON-COVALENT APPROACH BY SOLVENT DROP GRINDING METHOD | Zendy

Iyan Sopyan | Zendy; INSAN SUNAN KURNIWAN SYAH | Zendy; DESI NURHAYTI | Zendy; Arif Budiman | Zendy

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IMPROVEMENT OF SIMVASTATIN DISSOLUTION RATE USING DERIVATIVE NON-COVALENT APPROACH BY SOLVENT DROP GRINDING METHOD

Author(s) -

Iyan Sopyan,

INSAN SUNAN KURNIWAN SYAH,

DESI NURHAYTI,

Arif Budiman

Publication year - 2019

Publication title -

international journal of applied pharmaceutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.238

H-Index - 15

ISSN - 0975-7058

DOI - 10.22159/ijap.2020v12i1.35865

Subject(s) - dissolution , solubility , differential scanning calorimetry , chemistry , endothermic process , fourier transform infrared spectroscopy , nuclear chemistry , solvent , chromatography , organic chemistry , chemical engineering , adsorption , physics , engineering , thermodynamics

Objective: This study aimed to enhance the solubility of simvastatin using noncovalent derivatives (NCDs) with oxalic acid (OA), fumaric acid (AF), and nicotinamide (NK) as conformers. Methods: NCDs were prepared using by a solvent drop grinding (SDG). The NCDs formed were evaluated for saturated solubility test, NCDs with the highest saturation solubility were then characterized by Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimeter (DSC), powder x-ray diffractometry (PXRD) and the particulate dissolution using type II of USP test. Results: SV-OA NCDs showed the highest solubility; thus NCDS of SV-OA were characterized by X-ray diffraction showing a new peak at 2ϴ = 28.96 °C and differential scanning calorimeter showed a change of endothermic peak from 134.3 °C to 69 °C. Infrared spectroscopy indicated that there were no functional group changes from simvastatin, while the dissolution rate increased from 68.22% to 76.08%. Conclusion: SV-OA NCDs show an increased profile of solubility and dissolution compared to pure simvastatin.

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