Open AccessCO-CRYSTALS OF CARVEDILOL: PREPARATION, CHARACTERIZATION AND EVALUATION
Author(s) -
Raju Thenge,
Rakesh P. Patel,
Nandu Kayande,
Nilesh Mahajan
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2020v12i1.35640
Subject(s) - dissolution , solubility , differential scanning calorimetry , glutaric acid , fourier transform infrared spectroscopy , succinic acid , materials science , cocrystal , crystallization , nuclear chemistry , chemistry , chemical engineering , analytical chemistry (journal) , crystallography , organic chemistry , hydrogen bond , molecule , physics , engineering , thermodynamics
Carvedilol an antihypertensive drug, exhibit poor solubility and dissolution rate. Hence an attempt has been made to prepare the Co-crystals of Carvedilol to increase the solubility and dissolution rate by solvent evaporation method using coformer such as succinic acid, fumaric acid and oxalic acid. The prepared Co-crystals were evaluated for solubility, dissolution rate and micromeritic properties. The Co-crystals were characterized by scanning electronic Microscopy (SEM), FT-Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and X-ray Diffractometry (XRD). The CAR-SA Co-crystal, CAR-FA Co-crystals and CAR-OA Co-crystals showed increased in solubility and dissolution rate compared to pure Carvedilol. The Co-crystals formed with coformer have showed improved micromeritic properties. SEM clearly showed the formation of new solid phase with the coformer. The FT-IR spectra indicate the shifting of characteristic peak in the Co-crystals but does not showed any interaction between the coformer used. DSC data showed the change in the endotherm with the melting points of Co-crystals. XRD spectra indicate the notified difference in the 2θ and the intensity of the peaks. Hence the Co-crystal formation could be helpful to improve the solubility, dissolution and micromeritic properties of Carvedilol.