Open AccessFORMULATION AND EVALUATION OF TELMISARTAN FAST DISSOLVING TABLETS USING JACK FRUIT SEED STARCH AS SUPERDISINTEGRANT
Author(s) -
Sundeep Mupparaju,
S. Vidyadhara,
Sandeep Doppalapudi,
L C Sasidhar Reddyvallam,
Ramu Anne,
Siva Prasad Sunkara
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019v11i5.34072
Subject(s) - croscarmellose sodium , starch , chemistry , sodium hydroxide , fourier transform infrared spectroscopy , solubility , dissolution , phytochemical , telmisartan , differential scanning calorimetry , granulation , nuclear chemistry , chromatography , food science , materials science , chemical engineering , dosage form , biochemistry , organic chemistry , magnesium stearate , medicine , physics , blood pressure , engineering , composite material , radiology , thermodynamics
Objective: The main objective of the current study is to enhance the solubility of Biopharmaceutical Classification System (BCS) Class-II drug Telmisartan using jack fruit seed starch as super disintegrant which increases drug release.
Methods: Starches were extracted using alkali technique using sodium hydroxide at 0.1%, 0.25%, and 0.5% concentrations and water from Jack fruit seed powder. These starches were evaluated for various phytochemical and physicochemical tests. Fast dissolving tablets were prepared using Telmisartan, jack fruit seed starch and Croscarmellose sodium in various concentrations using wet granulation technique. Various pre and post-compression parameters were evaluated along with in vitro drug release studies, characterization studies like Fourier Transform Infra-Red spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and accelerated stability studies.
Results: Phytochemical tests revealed the presence of only starch in all the extracts. The starch prepared from 0.1% sodium hydroxide (JFS2) showed best physicochemical properties. From in vitro dissolution studies, it was observed that formulations F5 and F11 containing 15% w/w of JFS2 and 15% w/w of croscarmellose sodium showed faster disintegration and increased dissolution rate compared with other formulations. FTIR and DSC studies showed that there were no major interactions among drug and excipients. XRD studies revealed the nature of formulations. Accelerated stability studies revealed the stability of tablets.
Conclusion: Thus, the tablets prepared using Jack fruit seed starch revealed the super disintegrant property of starch.