Open AccessENERGY SAVINGS ON CURCUMINE DERIVATIVE GAMAVUTON-0 SYNTHESIS USING MICROWAVE IRRADIATION
Author(s) -
Sabtanti Harimurti,
Winny Setyo Nugroho,
Ardi Pramono
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019v11i3.31979
Subject(s) - microwave , microwave irradiation , energy consumption , irradiation , materials science , hydrochloric acid , acetone , nuclear chemistry , chemistry , catalysis , process engineering , organic chemistry , computer science , physics , engineering , telecommunications , nuclear physics , electrical engineering
Objective: The aim of this study was to develop a more effective and environmentally friendly synthesis method for anti-cancer curcumine derivatives, namely 1,5-bis (4’-hydroxy-3’-metoxyfenyl)-1,4-pentadiene-3-one or gamavuton-0.
Methods: The experiment was conducted using two different energy sources, i.e. conventional heating and microwave irradiation. Vanillin and acetone were used as starting materials, and hydrochloric acid as the catalyst. During synthesis, variations in the synthesis period were carried out to study the effect of time on the gamavuton-0 produced. Based on experimental data, energy consumption between conventional method and microwave were evaluated.
Results: Evaluation of energy consumption was calculated based on experimental data. It was found that energy consumption for production using microwave irradiation was reduced to 0.0014 kWh/gram of crude gamavuton-0 products from 0.19 KWh/gram of crude gamavuton-0 product using conventional heating.
Conclusion: Based on calculations from experimental data, microwave irradiation during the synthesis of gamavuton-0 significantly saves energy consumption for synthesis.