Open AccessEFFECT OF CENTELLA ASIATICA L. ON THE NUMBER OF OSTEOCLASTS, OSTEOBLASTS, AND OSTEOCYTES IN THE TIBIAE OF OVARIECTOMIZED RATS
Author(s) -
Vanissa Karis,
Sri Angky Soekanto,
Erik Idrus
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s1.ar171
Subject(s) - centella , ovariectomized rat , h&e stain , body weight , osteoblast , chemistry , staining , medicine , traditional medicine , pathology , biochemistry , estrogen , in vitro
Objective: This study aimed to examine the effectiveness of Centella asiatica L. as a phytoestrogen.Methods: Therapy using C. asiatica extract at doses of 60 mg/kg body weight, 120 mg/kg BW, and 180 mg/kg BW was administered to ovariectomizedrats for 30 days.Results: Histological examination using hematoxylin and eosin staining demonstrated an increased number of osteocytes and a decreased number ofosteoclasts, but there was no significant increase in osteoblast numbers.Conclusion: The administration of the low doses of C. asiatica extract affects the number of osteocytes and osteoclasts but not osteoblasts inovariectomized rats.