Open AccessTHE POTENCY OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA ROXB.) ETHANOL EXTRACT TO ERADICATE WILD STRAIN CANDIDA ALBICANS BIOFILM
Author(s) -
Ayu Diah Lestari,
Ria Puspitawati,
Ariadna Adisattya Djais
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s1.150
Subject(s) - candida albicans , biofilm , corpus albicans , curcuma , curcumin , potency , ethanol , minimum inhibitory concentration , microbiology and biotechnology , chemistry , traditional medicine , yeast , antimicrobial , antifungal , biology , in vitro , biochemistry , bacteria , medicine , genetics
Objective: The pathogenic yeast Candida albicans forms biofilm to increase its resistance toward antifungal agents. Javanese turmeric is an Indonesianmedicinal plant reported to have antifungal effects due to the active component, xanthorrhizol. The objective of this study was to measure the in vitropotential of Javanese turmeric ethanol extract to eradicate C. albicans biofilm.Methods: C. albicans was exposed to Javanese turmeric ethanol extract for 1 h during biofilm formation phases. MTT assay was used to test thepercentage of biofilm eradication.Results: The minimum inhibitory concentration and minimum fungicidal concentration of Javanese turmeric ethanol extract against planktonicC. albicans were 15%. The minimum biofilm eradication concentration (MBEC50) was 25% in the early phase and 15% in the intermediate andmaturation phases.Conclusions: Javanese turmeric ethanol extract is effective at eradicating clinical isolate of C. albicans biofilm.