Open AccessEFFECT OF JAVANESE TURMERIC ETHANOL EXTRACT ON THE ERADICATION OF CANDIDA ALBICANS BIOFILMS IN EARLY, INTERMEDIATE, AND MATURATION PHASES
Author(s) -
Beta Belatrix,
Ria Puspitawati,
Ariadna Adisattya Djais
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s1.148
Subject(s) - biofilm , candida albicans , corpus albicans , microbiology and biotechnology , ethanol , chemistry , biology , bacteria , biochemistry , genetics
Objectives: The aim of this research was to observe the effect of Javanese turmeric ethanol extract (JTEE) on the eradication of Candida albicans invarious phases of biofilm development.Methods: C. albicans biofilms were exposed to JTEE at a concentration 1–45% for 1 h. Cell viability was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the wavelength was read at 570 nm.Results: The results showed that the 50% minimal biofilm eradication concentration was 30% in the early phase, 20% in the intermediate phase, and25% in the maturation phase of the biofilm. The eradication percentage increased along with increasing JTEE concentration, but decreased with theage of the biofilm.Conclusion: We concluded that JTEE has the potential to eradicate C. albicans biofilms in various phases of development.