Open AccessINFLUENCE OF THE COMBINATION OF PASAK BUMI ROOT AND PROPOLIS EXTRACTS ON PARASITEMIA LEVELS IN MICE INFECTED WITH PLASMODIUM BERGHEI
Author(s) -
Nur Hasanah,
Hendri Astuty
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s1.015
Subject(s) - parasitemia , propolis , plasmodium berghei , artemisinin , malaria , traditional medicine , positive control , combination therapy , medicine , body weight , pharmacology , plasmodium falciparum , immunology
Objective: Malaria infection remains a global concern due to increasing resistance to artemisinin-based combination therapy. This study examinedthe antimalarial effects of propolis extract alone and in combination with pasak bumi root extract.Methods: In the study, 30 mice were divided into six groups including two control groups, two groups of mice treated with propolis aloneat concentrations of 90 and 180 mg/kg body weight (BW), and two combination groups of mice treated with 90 or 180 mg/kg BW propolis incombination with 60 or 75 mg/kg BW pasak bumi, respectively. Plasmodium berghei 2% was injected into each mouse, and blood smears wereprepared after 8 days to assess parasitemia.Results: The results revealed no significant difference in parasitemia levels between the positive control and the two combination groups (p=0.136 and0.289, respectively). However, superior growth inhibition (GI) results were observed in the combination groups (97.97% and 97.83%, respectively)than in the propolis monotherapy groups, whereas better outcomes were observed in the positive control group (98.63% GI) than in the propolismonotherapy groups (23.88% and 51.66%, respectively).Conclusion: These results illustrate that combination therapy is superior to propolis monotherapy in inhibiting parasitemia.