Open AccessEFFECTIVENESS OF PROPOLIS WITH ARTEMISININ COMBINATION THERAPY IN TREATING MICE INFECTED WITH PLASMODIUM BERGHEI
Author(s) -
Nurindah Saloka Trisnaningrum,
Hendri Astuty
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s1.012
Subject(s) - propolis , plasmodium berghei , artemisinin , combination therapy , body weight , pharmacology , medicine , traditional medicine , malaria , immunology , plasmodium falciparum
Objective: This study aimed to ascertain the effectiveness of combination treatment with propolis and artemisinin-based combination therapy (ACT)in avoiding further resistance to ACT.Methods: A total of 35 mice were injected with Plasmodium berghei and divided into six equal groups: No treatment (negative control), ACT alone(positive control), 75-mg propolis/kg body weight (BW), 150-mg propolis/kg BW, ACT with 75-mg propolis/kg BW, and ACT with 150-mg propolis/kg BW. After 7 days of therapy, parasite density was calculated using a thin blood smear.Results: Parasite density significantly declined after combination treatment with ACT and 150-mg propolis/kg BW.Conclusion: Therapy with propolis alone showed no inhibitory effect on parasites, although its 150-mg/kg-BW dose was effective as an ACT adjuvantmalaria therapy in mice.