Open AccessPREPARATION AND CHARACTERIZATION OF EDIBLE OIL NANOEMULSIONS FOR ENHANCED STABILITY AND ORAL DELIVERY OF CURCUMIN
Author(s) -
Jonathan Sampath Franklyne,
Abinaya Nadarajan,
Andrew Ebenazer,
Nisha Tiwari,
Amitava Mukherjee,
N. Chandrasekaran
Publication year - 2018
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2018v10i6.28726
Subject(s) - curcumin , bioavailability , chemistry , dispersity , chromatography , emulsion , aqueous solution , titration , pharmacology , organic chemistry , medicine , biochemistry
Objective: This work aims to improve the oral bioavailability and long-term aqueous stability of curcumin using various edible oil nanoemulsions (NEs).Methods: NEs were optimized using the water titration method. Curcumin was loaded into optimized emulsions, and the physicochemical characteristics were determined. Long-term stability of curcumin in the edible oil NEs was analyzed by determining the droplet size, PDI and curcumin concentrations over 4 mo. Release of curcumin from the NEs was determined using a Franz diffusion apparatus and analysed using 5 mathematical models.Results: The absorbance of curcumin was linear over the concentration range of 1 to 10 μg. ml-1. The LOD and LOQ ranged from 0.57 to 1.26μg. ml-1 and 1.89 to 4.19μg. ml-1 respectively. All the NEs were monodisperse and had a droplet size less than 150 nm. Long-term emulsion stability shows no change in droplet size and PI (Dunnett's multiple comparisons test with a confidence interval of 95%). Olive oil NE showed significantly low release in gastric fluid (9.28%) with a good release (92.99%) in intestinal fluid and 48% in a body fluid by 8 h.Conclusion: The work highlights the use of olive oil NEs as a delivery vehicle for curcumin with excellent release characteristics and the ability to protect curcumin in an aqueous environment.