Open AccessSIDE EFFECTS MONITORING OF AMINOGLYCOSIDE ANTIBIOTIC IN HOSPITALIZED PATIENTS
Author(s) -
Santi Purna Sari,
Siti Syarah Sartika,
Alfina Rianti
Publication year - 2018
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2018.v10s1.64
Subject(s) - ototoxicity , amikacin , aminoglycoside , gentamicin , antibiotics , medicine , nephrotoxicity , medical record , drug , observational study , side effect (computer science) , pharmacology , chemotherapy , toxicity , chemistry , biochemistry , computer science , cisplatin , programming language
Objective: The aim of this study was to monitor the side effects in patients who received aminoglycoside antibiotics at the inpatient service ofFatmawati Hospital from March to May 2017.Methods: This was an observational study based on data collected through patient interview, prescribing information, and medical records. Datawere collected on all inpatients treated with aminoglycosides during the study period (total sampling method). The Naranjo algorithm was used toassess the causality of the observed effects.Results: The data from 33 patients were evaluated, among whom 14 (42.4%) developed nephrotoxicity and 5 (15.2%) had ototoxicity. Based on theNaranjo algorithm analysis, the five cases of ototoxicity were categorized as probable drug side effects. No correlation was found between any of theside effects and either age (p=0.726) or sex (p=0.620).Conclusion: In this evaluation of the side effects attributable to aminoglycoside antibiotics in hospitalized patients, nephrotoxicity was the mostcommon, followed by ototoxicity. The latter was deemed probable drug-related side effects based on the Naranjo algorithm. Of the other side effects,twice as many were considered probable as those thought to be possible drug side effects. Neither age nor sex was significantly related to the adverseeffects secondary to gentamicin or amikacin.