Open AccessFORMULATION OF SUSPENDING VEHICLES FOR EXTEMPORANEOUS ORAL LIQUID COMPOUNDING WITH DILTIAZEM HYDROCHLORIDE AS A DRUG MODEL
Author(s) -
Sutriyo,
Zahra Meilia Nisa
Publication year - 2018
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2018.v10s1.51
Subject(s) - chemistry , chromatography , compounding , diltiazem hydrochloride , odor , diltiazem , hydrochloride , pharmacology , medicine , organic chemistry , calcium
Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stableformulation containing diltiazem hydrochloride (DTZ).Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests wereperformed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated.Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stabilitytests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry.Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ arephysically stable but not chemically stable during storage.