Open AccessALOE VERA ETHANOL EXTRACT AS A THERAPY FOR ALVEOLAR MANDIBLE REGENERATION IN LIPOPOLYSACCHARIDE-EXPOSED RATS
Author(s) -
Latifah Fitriani Rakhman,
Octaviana Widya Pangestika,
Delvi Fitriani,
Rudhanton Rudhanton,
Nur Permatasari
Publication year - 2018
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2018.v10s1.03
Subject(s) - aloe vera , dental alveolus , h&e stain , lipopolysaccharide , osteoclast , staining , regeneration (biology) , medicine , traditional medicine , pathology , dentistry , biology , receptor , microbiology and biotechnology
Objective: The study examined the effects of Aloe vera ethanol extract on alveolar mandible regeneration in rats (Rattus norvegicus).Methods: Rats were divided into five groups as follows: Negative control group received no treatment, positive control group received Escherichiacoli lipopolysaccharide (LPS) alone for 5 days, and Groups P1, P2, and P3 received LPS for 5 days followed by 40, 80, and 160 mg/kg BW A. veraethanol extract, respectively, orally on days 6–12. Alveolar bone tissues were taken and histologically processed through hematoxylin-eosin staining.Osteoblast and osteoclast numbers in alveolar tissue were also examined.Results: One-way ANOVA revealed strong relationships between the A. vera ethanol extract dosage and the numbers of osteoblasts (r=0.921, p<0.05)and osteoclasts (r=−0.631, p<0.05) in rats.Conclusion: A. vera ethanol extract appears capable of stimulating alveolar bone regeneration following LPS exposure.