Open AccessENZYMATIC DEGRADATION OF CROSS-LINKED EXCIPIENT MATRIX OF CO-PROCESSED XANTHAN GUM-AMYLOSE AND DISSOLUTION PROFILE OF DICLOFENAC SODIUM TABLET
Author(s) -
Silvia Surini,
Nurul Nizma,
Azizahwati Azizahwati
Publication year - 2017
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2017.v9s1.42_48
Subject(s) - excipient , chemistry , xanthan gum , diclofenac sodium , amylose , chromatography , matrix (chemical analysis) , starch , food science , materials science , rheology , composite material
Objectives: This study aims to determine the amount of excipient that is degraded by alpha-amylase and the influence of alpha-amylase to thedissolution profile of sustained-release tablets that use matrix CL-Co-A-XG.Methods: Excipient is cross-linked with two concentrations of sodium trimetaphospate, which are 6% (CL6-Co-A-XG) and 12% (CL12-Co-A-XG).Each excipient is made with the ratios 1:1, 1:2, and 2:1 amylose-xanthan gum. Enzymatic degradation tests are performed on excipient powders for60 minutes. Sustained-release tablet with CL-Co-A-XG excipient as a matrix is formulated through direct compression method. Then, drug dissolutiontests are performed in a phosphate buffer with a pH of 7.4 both using and without using alpha-amylase as a medium for 8 hrs.Results: The results of this study show that CL6-Co-A-XG and CL12-Co-A-XG degraded 20% at 10 and 30 minutes, respectively. In addition, the releaseprofile of F1-F6 tablets show the sustained-release profile that follows zero-order and Korsmeyer–Peppas kinetics and is unaffected by the presenceof alpha-amylase.Conclusions: From this study, it can be concluded that the CL-Ko-A-XG excipients are more resistant to enzymatic degradation than amylose. Therefore,this excipient shows potential as a single matrix sustained-release tablet.