Open AccessFORMULATION AND PHYSICAL STABILITY TEST OF GRISEOFULVIN MICROEMULSION GEL
Author(s) -
Anindya Hana Iradhati,
Mahdi Jufri
Publication year - 2017
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2017.v9s1.22_27
Subject(s) - microemulsion , griseofulvin , chromatography , chemistry , solubility , oleic acid , pulmonary surfactant , organoleptic , materials science , organic chemistry , food science , medicine , biochemistry , dermatology
Objective: The main objective of this research is to make and evaluate the formulation of a griseofulvin microemulsion gel for topical use to increasethe solubility and safety of the drug.Methods: The optimized microemulsion formula contains 5% oleic acid as the oil phase, 25% Tween 80 as the surfactant, and 20% ethanol (96%)as the cosurfactant.Results: Organoleptic observations of the microemulsion showed that it had a clear and transparent yellowish color, while the microemulsion gel hada hazy yellowish color. Both the microemulsion and the microemulsion gel had the smell of alcohol. The size of the globules in the microemulsion andthe microemulsion gel was 158.0 nm and 226.0, respectively.Conclusions: The griseofulvin microemulsion gel was stable at 4°C±2°C, 25°C±2°C, and 40°C±2°C.